Depression is a prevalent psychological condition that exists in many forms. Symptoms include a loss of interest in activities, sleep disruption, appetite changes, suicidal thoughts and feelings of guilt or worthlessness. For some, depression is mild and brief; for others, it is debilitating and chronic. It can be related to life events or can come out of the blue. Regardless of its genesis or severity, depression can be treated and, if not eliminated, significantly reduced with cognitive-behavioral therapy.